xm in length, depending on muscle type.The two important regulatory proteins in striated muscles,tropomyosin and troponin, are entwined with two actinstrands. The tar-gets were arrayed onto slides in a set format thatdid not reflect functional or structural classifica-tion. The distinction is important because ini-tial treatment of catatonia differs significantly from treat-ment of these other syndromes. The cornerstone of clinical research is trust: patients’ trust that investi-gators will consider and respect their safety and well-being, investigators’ trust in thevalidity of others’ ? ndings and their data, and society’s trust that research resourceswill be properly allocated and ?ndings used to bene?t society at large (Council 2009 ).To help understand the ethical challenges of clinical neurosurgical research, thischapter reviews important principles related to research practice in neurosurgicalpopulations.

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