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The strongly electrophilicnature of O enables it to attack carbon double bonds. Effects of losartan on renal and cardiovascularoutcomes in patients with type 2 diabetes and nephropathy. GJB2 genotyping has alsoguided clinical predictions of deafness severity

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This isassociated with release of PGD2 in the skin, andcan be minimized by starting with a low dosetaken with meals and gradually increasing astolerance develops.

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